Search results for "Joint Contracture"

showing 3 items of 3 documents

Multiple congenital contractures (Congenital multiple arthrogryposis)

2002

Arthrogryposis, is the occurrence of joint contractures of variable etiology that start prenatally. Arthrogryposis may result from neurologic deficit, neuromuscular disorders, connective tissue abnormalities, amniotic bands, [figure: see text] or fetal crowding. Arthrogryposis may result from no apparent hereditary causes (neuropathic, for example) or may be the result of hereditary factors (myopathic form, for example). Ultrasound diagnosis depends on observation of scant or absent motion of fetal extremities. Prognosis depends on the specific etiology of the contractures.

Pathologymedicine.medical_specialtyAmniotic BandConnective tissueNeurological disorderUltrasonography PrenatalPregnancyHumansMedicineAbnormalities MultipleJoint ContractureFetal MovementMuscle contractureArthrogryposisArthrogryposisbusiness.industryObstetrics and GynecologyExtremitiesSyndromemedicine.diseasemedicine.anatomical_structurePediatrics Perinatology and Child HealthFetal movementEtiologyFemalemedicine.symptombusinessJournal of Perinatal Medicine
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<p>Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model</p>

2019

Background After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic joint stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems. Objective The purpose of this study was the evaluation of the influence of losartan and atorvastatin on the early development of joint contracture. In addition to joint angles, the change in myofibroblast numbers and the distribution of bone sialoprotein (BSP) were assessed. Study design and methods In this randomized and blinded experimental study with 24 rats, losartan and atorvastatin were compared to a placebo. After an initial joint injury, rat knees were …

musculoskeletal diseases0301 basic medicinePharmacologymedicine.medical_specialtyArticular capsule of the knee jointbusiness.industryAtorvastatinUrologyPharmaceutical SciencePlacebo03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structureLosartan030220 oncology & carcinogenesisJoint stiffnessDrug DiscoveryJoint capsulemedicineJoint Contracturemedicine.symptomContracturebusinessmedicine.drugDrug Design, Development and Therapy
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Influence of the anti-inflammatory cytokine interleukin-4 on human joint capsule myofibroblasts

2016

Post-traumatic joint contracture was reported to be associated with elevated numbers of contractile myofibroblasts (MFs) in the healing capsule. During the physiological healing process, the number of MFs declines; however, in fibroconnective disorders, MFs persist. The manifold interaction of the cytokines regulating the appearance and persistence of MFs in the pathogenesis of joint contracture remains to be elucidated. The objective of our current study was to analyze the impact of the anti-inflammatory cytokine interleukin (IL)-4 on functional behavior of MFs. Cells were isolated from human joint capsule specimens and challenged with three different concentrations of IL-4 with or without…

musculoskeletal diseases0301 basic medicinemedicine.medical_treatmentInterleukinBiology03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structureCytokineJoint capsuleGene expressionImmunologyCancer researchmedicineOrthopedics and Sports MedicineJoint ContractureReceptorMyofibroblastInterleukin 4030215 immunologyJournal of Orthopaedic Research
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